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Camptothecin prodrug

WebOct 21, 2024 · A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations. Mitochondria are crucial regulators of the … WebDec 16, 2024 · A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane–naphthalimide fluorescent camptothecin …

Activation of a camptothecin prodrug by specific …

WebAbstract A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate linker. The conjugate was found to possess high affinity for folate receptor-expressing cells and inhibited cell proliferation in human KB cells with an IC 50 of 10 nM. WebThe PEG-CPT prodrug is obtained by conjugation of a 40 ... Camptothecin is a natural compound isolated from the plant camptotheca accuminata. The sodium salt of … ts-tech人事 https://dpnutritionandfitness.com

Case Study: Irinotecan (CPT-11), A Water-soluble Prodrug of SN …

WebJan 13, 2024 · Therapeutic conjugate approaches that alter the solubility of a conjugate “prodrug” have been used to enable NC formation and controlled release from NCs using labile linker chemistry. A limitation of this approach has been that a different linker chemistry must be used to produce an adjustable release rate for a single therapeutic. WebFeb 28, 2024 · Camptothecin (CPT) is a pentacyclic quinoline alkaloid drug, which possesses superior antitumor efficacy, antiproliferative effect and apoptosis induction capacity in colon, lung, breast, ovarian, melanoma and other cancers. WebIntroduction. Camptothecin (CPT) is a naturally occurring alkaloid with potent antineoplastic activity against a broad spectrum of solid tumors (eg, primary and metastatic colon carcinoma, small cell lung carcinoma, and ovarian, breast, pancreatic, and stomach cancers), which inhibits DNA topoisomerase I. 1 SN38 (7-ethyl-10-hydroxyl … phlebotomy free practice test exam

Methotrexate–Camptothecin Prodrug Nanoassemblies as a …

Category:A GSH-Responsive Nanoprodrug System Based on Self-Assembly …

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Camptothecin prodrug

Self-Assembled Disulfide Bond Bearing Paclitaxel—Camptothecin Prodrug ...

WebGlucuronide camptothecin is a type of prodrug produced from camptothecin and glucuronide. Glucuronide, which is also referred to as glucuronoside, is substance produced by linking glucuronic acid to another substance via a glycosidic bond. The prodrug could catalyze and produce the drug camptothecin (CPT), which was discovered in 1966. WebIt is well known that camptothecin (CPT), which inhibits topoisomerase Ⅰ activity, has significant anticancer activity against various solid tumors in vitro. 29, 30 However, the major problem encountered with CPT is its extremely low solubility and side effects, which lead to the failure of clinical treatment. 31 In order to overcome the problem, …

Camptothecin prodrug

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WebDespite the use of intensive multimodality therapy, the majority of high-risk neuroblastoma (NB) patients do not survive. Without significant improvements in delivery strategies, anticancer agents used as a first-line treatment for high-risk tumors often fail to provide clinically meaningful results in the settings of disseminated, recurrent, or refractory … WebCamptothecin and lactose act as the chemotherapy drug and targeting ligand in the drug delivery system, respectively. Since CPT-S-S-LA is an amphiphilic compound, it can self-assemble into nanoparticles with a diameter of around 110 nm. The CPT-S-S-LA nanoparticles displayed controllable drug release behavior in the physiological environment.

WebDOI号:文献链接:文献作者:备注信息: Camptothecin-doxorubicin prodrug and its preparation method and application WebFeb 4, 2024 · Conventional chemotherapy and targeted therapy promote the antitumor immune response by increasing the immunogenicity of tumor cells, improving CD8+ T cell infiltration, or inhibiting immunosuppressive cells in the tumor microenvironment.

WebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH … WebIrinotecan is a prodrug designed to deliver the poorly soluble parent molecule SN-38, an analog of a highly potent plant alkaloid camptothecin (CPT). Camptothecin and its analogs inhibit the nuclear enzyme topoisomerase I, inhibiting replication and demonstrating antitumor activity as an S-phase-specific drug ( Garcia-Carbonero and Supko, 2002 ).

WebAug 12, 2024 · Camptothecin (CPT), a potent chemotherapeutic against various cancers, including CRC, has shown the potential to enhance CTL-mediated tumour …

WebDec 5, 2024 · The highly toxic payloads, for instance, maytansine, camptothecin derivatives, auristatin, or doxorubicin are recommended to choose in the conjugates. 9 Finally, ... To create a TfR targeted prodrug of DM1, the TfR binding peptide B6 was designed to conjugate with DM1 through the side chain of cysteine at the C-terminus via … phlebotomy fun factsWebOct 15, 2006 · A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate … phlebotomy free trainingWebSep 18, 2024 · MTX and 10-hydroxyl camptothecin (CPT) were chosen to conjugate through ester linkage. Because of the amphiphilicity and ionicity, MTX-CPT conjugates … ts tech uk swindon