WebOct 21, 2024 · A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations. Mitochondria are crucial regulators of the … WebDec 16, 2024 · A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane–naphthalimide fluorescent camptothecin …
Activation of a camptothecin prodrug by specific …
WebAbstract A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate linker. The conjugate was found to possess high affinity for folate receptor-expressing cells and inhibited cell proliferation in human KB cells with an IC 50 of 10 nM. WebThe PEG-CPT prodrug is obtained by conjugation of a 40 ... Camptothecin is a natural compound isolated from the plant camptotheca accuminata. The sodium salt of … ts-tech人事
Case Study: Irinotecan (CPT-11), A Water-soluble Prodrug of SN …
WebJan 13, 2024 · Therapeutic conjugate approaches that alter the solubility of a conjugate “prodrug” have been used to enable NC formation and controlled release from NCs using labile linker chemistry. A limitation of this approach has been that a different linker chemistry must be used to produce an adjustable release rate for a single therapeutic. WebFeb 28, 2024 · Camptothecin (CPT) is a pentacyclic quinoline alkaloid drug, which possesses superior antitumor efficacy, antiproliferative effect and apoptosis induction capacity in colon, lung, breast, ovarian, melanoma and other cancers. WebIntroduction. Camptothecin (CPT) is a naturally occurring alkaloid with potent antineoplastic activity against a broad spectrum of solid tumors (eg, primary and metastatic colon carcinoma, small cell lung carcinoma, and ovarian, breast, pancreatic, and stomach cancers), which inhibits DNA topoisomerase I. 1 SN38 (7-ethyl-10-hydroxyl … phlebotomy free practice test exam