WebJun 8, 2024 · Methotrexate can cause serious or fatal side effects. Call your doctor at once if you have: sudden chest pain, wheezing, dry cough, cough with mucus, feeling short of breath; ... high cholesterol, heart problems, high blood pressure, seizures, pain, or arthritis (including Tylenol, Advil, Motrin, or Aleve). Tell your doctor about all your other ... WebJun 13, 2024 · Methotrexate can cause different brain or spinal cord problems that cause seizures, confusion, or blindness. Though rare, this can even occur with low doses of …
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