WebDepleting MUF resulted in ~50% downregulation of Snail1, ~40% downregulation of vimentin, ~60% downregulation of CTGF, and ~30% downregulation of c-Myc in T98G cells and U87-MG cells (Figure 4B). Several other TGF-β-regulated genes did not show any change in expression with MUF knockdown . Since lncRNA-MUF depletion inhibits … WebFor example, the lncRNA B4GALT1-AS1 can directly bind to YAP to promote its nuclear translocation, while the lncRNA LEF1-AS1 directly interacts with the LATS1 protein, abolishing the interaction between LATS1 and MOB and leading to inactivation of the Hippo pathway. 61,62 LncRNAs can also indirectly influence the Hippo pathway by interacting ...
CTGF regulates cell proliferation, migration, and glucose
WebSep 28, 2024 · The etiology of polycystic ovary syndrome (PCOS) is complex and the pathogenesis is not fully understood. Some studies … WebDec 12, 2024 · During the proliferative phase of diabetic wound healing, lncRNA H19 recruits the transcription factor SRF to the CTGF promoter region, activating CTGF and its downstream MAPK signaling pathway to accelerate fibroblast proliferation and wound healing. These findings elaborate lncRNA H19 as a regulator in the regenerative phase … kenneth flicker repairs
Long noncoding RNA GAS5 inhibits progression of colorectal …
WebE. Expression analysis of LITATS1, PAI-1, CTGF, and SMAD7 in MCF10A-M2 cells upon CRISPRa-mediated LITATS1 overexpression. Representative results from a minimum of three independent experiments are shown. ... TGF-β signaling can induce the expression of multiple lncRNAs, e.g., lncRNA-ATB and lncRNA-HIT, which function as effectors of … WebApr 23, 2024 · LncRNA PFAL was found to have profibrotic activity, which manifested itself upon the inhibition of miR-18a. ... (TGF-β1) and connective tissue growth factor (CTGF) in acute respiratory distress ... kenneth fletcher obituary