WebNational Center for Biotechnology Information WebApr 23, 2024 · Vancomycin also inhibits transglycosylase (glycosyltransferase), a second enzyme responsible for cross-linking sugar residues, although this appears to be a less important mechanism compared to inhibition of transpeptidase. The mechanism for transglycosylase inhibition is unclear. ... Nephrotoxicity (rare with current preparations; ...

Mechanisms of antimicrobial-induced nephrotoxicity in children

WebVancomycin-induced nephrotoxicity is a commonly feared and largely preventable adverse effect of vancomycin therapy. We present the case of a 56-year-old woman who … WebThe mechanisms that underlie the pathogenesis of vancomycin nephrotoxicity are multifactorial but include interstitial nephritis, tubular injury due to oxidative stress, and … i\u0027m little bit off today

National Center for Biotechnology Information

WebVancomycin is considered one of the most common antibiotics used globally for treating severe Gram-positive infections caused by meticillin-resistant S aureus (MRSA) [5,46]. Nevertheless, vancomycin has long been recognized as one of the most commonly encountered drugs that induces nephrotoxicity and hepatotoxicity. WebApr 19, 2016 · The exact mechanism of vancomycin-induced nephrotoxicity is unknown, but it has been suggested that oxidative stress and hypoxia may be involved in the pathogenesis [3,4]. Since vancomycin is secreted by the renal proximal tubule, it is hypothesized that this is the site where vancomycin-induced nephrotoxicity takes place [ 5 ]. WebSep 21, 2012 · Vancomycin (VCM)'s nephrotoxicity limits its application and therapeutic efficiency. The aim of this study was to determine the protective effect of rhein against VCM‐induced nephrotoxicity (VIN). i\\u0027m little sick right but i swear