WebPilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound. Pilocarpine, in appropriate dosage, can increase secretion by the exocrine glands. The sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. WebDec 24, 2024 · The present experiments reveal the alterations of the hippocampal neuronal populations in chronic epilepsy. The mice were injected with a single dose of pilocarpine. They had status epilepticus and spontaneously recurrent motor seizures. Three months after pilocarpine treatment, the animals were investigated with the Barnes maze to determine …
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WebPilocarpine is a nonselective muscarinic agonist with a relatively high affinity for CNS muscarinic receptors. It is commonly used to induce an experimental model of temporal lobe epilepsy. In different animal species, intraperitoneal injection of pilocarpine leads to a convulsive status epilepticus (SE) that persists for several hours. WebAug 1, 2011 · N2 - After pilocarpine-induced status epilepticus, many granule cells born into the postseizure environment migrate aberrantly into the dentate hilus. Hilar ectopic granule cells (HEGCs) are hyperexcitable and may therefore increase circuit excitability. This study determined the distribution of their axons and dendrites. getting through grief during the holidays
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WebN2 - Pilocarpine HCl and β-cyclodextrin kneading complex was entrapped in niosomes followed by dispersion in hydroxypropylmethylcellulose gel. In-vitro release studies showed that the product exhibited slow release compared with release of plain drug. In-vivo studies also showed miotic action for a longer duration indicating the slow and ... WebFeb 1, 2024 · Pilocarpine tablets are used to treat dryness of the mouth and throat caused by a decrease in the amount of saliva that may occur after radiation treatment for cancer … WebIt seems that the use of pilocarpine mouthwash can increase the salivary flow rates; however, no optimal dose and application regimen can currently be suggested due to the high heterogeneity of the data. ... Pilocarpine may be a useful medication for the treatment of xerostomia, but its side effects limit its use under certain conditions ... christopher j roche insurance agency